A clinical study of neurological soft signs in patients with schizophrenia

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The clinical correlates of neurological soft signs in chronic schizophrenia.

Among 16 chronic schizophrenic in-patients, all had at least one neurological soft sign (NSS), and 6 (40%) had definite neurodysfunction. NSS and TD scores were highly intercorrelated, and NSS were significantly correlated with neuroleptic drug exposure. NSS correlated positively with both positive and negative symptoms and cognitive impairment but not with cerebral ventricular size on CT. Pati...

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Neurological Soft Signs in First -Episode Schizophrenia

Neurological soft signs (NSS) refer to subtle neurological abnormalities comprising deficits in sensory integration, motor coordination, or sequencing of complex motor acts. It is generally accepted that NSS are more prevalent in schizophrenia patients, including first -episode cases, than in healthy subjects. Moreover, NSS have been consistently demonstrated in neuroleptic naïve firstepisode p...

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Potential endophenotype for schizophrenia: neurological soft signs.

INTRODUCTION Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. METHODS This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotyp...

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Neurological soft signs in schizophrenia: a meta-analysis.

BACKGROUND Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting...

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[Neurological soft signs as a candidate for endophenotype of schizophrenia].

A concept of an endophenotype, also termed as an internal endophenotype, is used in genetic studies on psychiatric disorders. Neurological soft signs are also considered candidates for endophenotypes of schizophrenia. Neurological soft signs are, objectively measured, non-localizing abnormalities, not related to impairment of a specific brain region, reflecting improper cortical-subcorical and ...

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ژورنال

عنوان ژورنال: Journal of Neurosciences in Rural Practice

سال: 2016

ISSN: 0976-3147,0976-3155

DOI: 10.4103/0976-3147.181481